ea0016p556 | Obesity | ECE2008
Behm Maria
, Ambrugger Petra
, Sauber Jeannine
, Hinney Anke
, Hebebrand Johannes
, Friedel Susann
, Bronner Gunter
, Wiegand Susanna
, Krude Heiko
, Gruters Annette
, Biebermann Heike
Objective: The increasing incidence of obesity is a major health problem world-wide. So far, mutations were identified in genes encoding major contributors in energy homeostasis. With the exception of mutations in the melanocortin-4-receptor gene (MC4R) obesity-causing mutations are very rare. To date great efforts were undertaken to identify gene variants that contribute to polygenic obesity. The GIPR belongs to the large superfamily of G-protein coupled recepto...